Understanding PTEN in Cancer
The role of PTEN feedback mechanism in cancer
This project explores how a key protein called PTEN works in cancer cells to help us find new ways to fight the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11074122 on NIH RePORTER |
What this research studies
Our bodies have a protein called PTEN that acts like a brake on cancer growth, but it often gets changed in human cancers. This project looks at how small changes to PTEN, called post-translational modifications, affect its ability to stop cancer. We are also exploring how PTEN works beyond its main pathway, including its role in keeping our genes stable and controlling cell division. By understanding these detailed mechanisms, we hope to uncover new targets for cancer treatments.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients directly but aims to benefit future patients with various cancers by improving our understanding of disease mechanisms.
Not a fit: Patients seeking immediate treatment options will not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for cancer treatment by targeting how PTEN functions in tumor cells.
How similar studies have performed: Previous studies, including work by this team, have shown that changes to PTEN can lead to cancer, and this project builds upon that established knowledge with novel investigations.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Song, Min Sup — University of Tx Md Anderson Can Ctr
- Study coordinator: Song, Min Sup
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.