Understanding proteins involved in ciliopathies
Discovery and characterization of novel ciliopathy protein complexes
This study is looking at ciliopathies, which are serious disorders caused by problems with tiny hair-like structures in our cells called cilia, and it aims to create a detailed map of the proteins that help these cilia work properly, so we can better understand how changes in these proteins can lead to health issues and improve care for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10685253 on NIH RePORTER |
What this research studies
This research investigates ciliopathies, a group of serious developmental disorders caused by dysfunctional cilia, which can lead to various health issues. The project aims to create a detailed map of protein complexes associated with cilia using advanced proteomic techniques. By identifying and characterizing these protein complexes, the research seeks to uncover how mutations related to ciliopathies disrupt normal cilia function. This could improve diagnosis and treatment options for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ciliopathies such as Joubert syndrome, Meckel syndrome, or Bardet-Biedl syndrome.
Not a fit: Patients with conditions unrelated to ciliopathies or those without genetic mutations affecting cilia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted treatments for patients with ciliopathies.
How similar studies have performed: Other research has shown promise in understanding ciliopathies through proteomic approaches, suggesting potential for success in this area.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Drew, Kevin — University of Illinois at Chicago
- Study coordinator: Drew, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.