Understanding proteins in colorectal cancer cells and tumors
Quantitative top-down proteomics of human colorectal cancer cells and tumors
This study is looking at the proteins in colorectal cancer cells to better understand how the disease works and how it might respond to treatments, especially for patients with Lynch Syndrome, so we can find better ways to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11015767 on NIH RePORTER |
What this research studies
This research focuses on analyzing the proteins present in colorectal cancer (CRC) cells and tumors to gain a deeper understanding of the disease at a molecular level. By developing new analytical tools for top-down proteomics, the study aims to identify different protein forms that may influence cancer progression and treatment responses. Patients' CRC cells and tumors will be examined before and after metastasis, particularly in those with Lynch Syndrome, to uncover critical insights that could lead to more effective therapies. The approach emphasizes the importance of protein-level information, which is often overlooked in traditional genomic studies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with colorectal cancer, especially those with Lynch Syndrome.
Not a fit: Patients with non-cancerous conditions or those not diagnosed with colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective therapies for colorectal cancer patients.
How similar studies have performed: While many studies have focused on bottom-up proteomics, this top-down approach is relatively novel and has the potential to provide new insights into colorectal cancer.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Sun, Liangliang — Michigan State University
- Study coordinator: Sun, Liangliang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.