Understanding protein structures using advanced techniques
Molecular Structure Determination by Mass Spectrometry and Computational Modeling
['FUNDING_R01'] · UNIVERSITY OF MISSISSIPPI · NIH-10916503
This study is looking at how proteins change and interact with their surroundings, using a special method to get a closer look, which could help us better understand how proteins work in the body and improve the information we have about them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MISSISSIPPI (nih funded) |
| Locations | 1 site (UNIVERSITY, UNITED STATES) |
| Trial ID | NIH-10916503 on ClinicalTrials.gov |
What this research studies
This research focuses on improving our understanding of protein structures, which are crucial for many biological processes. It employs a technique called hydroxyl radical protein footprinting (HRPF) to analyze how proteins interact with their environment at a detailed level. By measuring how proteins change over time and under different conditions, the research aims to create more accurate models of protein structures that are currently underrepresented in databases. This could lead to new insights into how proteins function and interact within the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein misfolding or dysfunction, such as certain autoimmune diseases or genetic disorders.
Not a fit: Patients with conditions unrelated to protein structure or function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted therapies and treatments for diseases related to protein dysfunction.
How similar studies have performed: Other research has shown success using similar techniques to study protein structures, indicating a promising avenue for further exploration.
Where this research is happening
UNIVERSITY, UNITED STATES
- UNIVERSITY OF MISSISSIPPI — UNIVERSITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHARP, JOSHUA S — UNIVERSITY OF MISSISSIPPI
- Study coordinator: SHARP, JOSHUA S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.