Understanding protein structures using advanced mass spectrometry techniques
Quantitative Determination of High-Order Protein Structure with Native Ion Mobility-Mass Spectrometry and Computational Chemistry
This study is looking at how proteins in our bodies work and interact, using a special technique that lets scientists see them in their natural state, which could help improve our understanding of health and diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project ID | NIH-10928226 on NIH RePORTER |
What this research studies
This research focuses on characterizing the structures and interactions of biomolecules, particularly proteins, which are crucial for understanding human health and disease. It employs Native Ion Mobility-Mass Spectrometry (IM-MS), a technique that allows for the analysis of proteins in their natural state, directly from solution. By using this method, researchers aim to overcome limitations of traditional techniques, making it possible to study small or complex protein samples that are difficult to analyze otherwise. The research also integrates computational chemistry to enhance the understanding of protein behavior and interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein misfolding or dysfunction, such as certain genetic disorders or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein structure or function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better insights into protein structures, potentially improving the development of therapeutics for various diseases.
How similar studies have performed: Other research has shown success using similar mass spectrometry techniques to analyze biomolecules, indicating a promising approach in this field.
Where this research is happening
Eugene, United States
- University of Oregon — Eugene, United States (Active)
Researchers
- Principal investigator: Prell, James Stephen — University of Oregon
- Study coordinator: Prell, James Stephen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.