Understanding Protein Shapes and Functions
Mapping Fitness & Free Energy Landscapes of Proteins
This project helps us understand how proteins work and change shape, especially those involved in conditions like AIDS and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11143742 on NIH RePORTER |
What this research studies
Our goal is to combine advanced computer modeling and genetic information to learn more about how proteins recognize other molecules and perform their jobs. We are particularly interested in proteins called kinases, which play a big role in many diseases, including cancer. By mapping out how these proteins change their shape, we hope to find new ways to design medicines that target them more effectively. This work could lead to new treatments for conditions like AIDS and certain cancers.
Who could benefit from this research
Good fit: This foundational research is relevant to patients living with AIDS or certain types of cancer, as it aims to improve future drug design.
Not a fit: Patients without conditions related to AIDS or kinase-driven cancers may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new, more specific medicines for AIDS and various cancers.
How similar studies have performed: This project integrates novel machine learning methods with established structural approaches to explore protein function.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Levy, Ronald — Temple Univ of the Commonwealth
- Study coordinator: Levy, Ronald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.