Understanding protein loss in children with heart and gut issues
Defining the lymphatic basis of protein losing enteropathy after Fontan palliation or inflammatory gut disease
This study is looking into why some kids with heart defects or certain gut diseases lose important proteins from their blood into their intestines, and it aims to find better ways to help them feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10884206 on NIH RePORTER |
What this research studies
This research investigates protein-losing enteropathy (PLE), a condition where proteins leak from the bloodstream into the intestines, particularly in children who have undergone Fontan palliation for heart defects or suffer from inflammatory bowel diseases like Crohn's disease. The study aims to identify the underlying causes of PLE, focusing on the integrity of the intestinal barrier and the function of lymphatic vessels. By examining how these factors contribute to protein loss, the research seeks to develop better treatment strategies for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have undergone Fontan palliation or have been diagnosed with inflammatory bowel diseases like Crohn's disease.
Not a fit: Patients who do not have protein-losing enteropathy or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for children suffering from protein-losing enteropathy, potentially reducing mortality rates associated with this condition.
How similar studies have performed: While the specific mechanisms of PLE are still being explored, there is existing literature suggesting that similar approaches to understanding lymphatic function and intestinal health have shown promise in related conditions.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Randolph, Gwendalyn J — Washington University
- Study coordinator: Randolph, Gwendalyn J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.