Understanding protein interactions in cancer for better treatments
Core 1: Functional Genomics and Proteomics
This study is looking at how proteins work together and how genes influence cancer, with the goal of finding better ways to personalize treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10911948 on NIH RePORTER |
What this research studies
This research focuses on systematically characterizing how proteins interact with each other and how genetic networks operate in cancer drivers. By utilizing advanced techniques like CRISPR genetic screens and proteomic technologies, the project aims to identify functional complexes that can help in stratifying patients and developing targeted therapies. The research will generate high-quality data on protein-protein interactions and genetic interactions, which will be analyzed to provide insights into the cancer landscape and guide personalized treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with various types of cancer who may benefit from targeted therapies based on their specific genetic and protein interaction profiles.
Not a fit: Patients with non-cancerous conditions or those whose cancer is not driven by the specific pathways being studied may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer therapies for patients.
How similar studies have performed: Previous research utilizing similar proteomic and genetic interaction approaches has shown promise in advancing cancer treatment strategies.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Krogan, Nevan J — University of California, San Francisco
- Study coordinator: Krogan, Nevan J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.