Understanding protein dynamics using computational methods
Official title: Development & application of computational methods for the study of protein dynamics with PmHMGR as a model system
Funded at University of Notre Dame · NIH-10913299 · Data updated 2026-11-12
This study is looking at how a specific protein works and interacts with others, which could help us understand diseases related to proteins better and lead to new treatments that might help patients in the future.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project start | August 25, 2023 |
| Project end | August 24, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31LM014204-02 |
| Project ID | NIH-10913299 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals with genetic disorders or diseases linked to protein dysfunction.
✕Less likely to help
Patients with conditions unrelated to protein dynamics or those not affected by protein dysfunction may not receive any benefit from this research.
What this research studies
This research focuses on investigating how proteins function and interact at a molecular level, particularly through the study of a specific protein called PmHMGR. By combining computational techniques with experimental data, the researchers aim to create detailed models that reveal the dynamic behavior of proteins over time. This approach allows for a deeper understanding of the mechanisms behind protein-related diseases, potentially leading to new treatment targets. Patients may benefit from insights gained through this research that could inform future therapies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases caused by protein dysfunction.
How similar studies have gone: Other research has shown success in using computational methods to study protein dynamics, indicating that this approach is both promising and validated.
Where this research is happening
-
University of Notre Dame
Notre Dame, United States Active
Researchers
- Principal investigator: Farrugia, Mikaela — University of Notre Dame
- Study coordinator: Farrugia, Mikaela
Related research
Other NIH-funded projects on the same topics.
-
Designer covalent blockers to stop IgE-driven allergic reactions
A new approach aims to block IgE antibodies that trigger allergic reactions in people with allergic asthma, potentially reducing severe symptoms without broad immune suppression.
-
A life-course view of how early adversity shapes health as people grow up
This NIH grant looks at how tough experiences in childhood and adolescence affect health and aging later in life, using data from people and animal studies to understand why some outcomes are worse and how social factors can help.
-
How a simple, evidence-based approach helps mothers and kids in Peru feel better
A study tests a flexible, lay-delivered mental-health program called CETA for mothers of young children in Lima to improve family well-being.
-
Open-Source tools to test conversational AI for dementia care
A multilingual AI benchmarking project aims to help improve chatbots and virtual assistants used in Alzheimer’s and related dementias, with open tools and datasets for researchers and clinicians.
-
Decoding how human CD8+ T cells recognize donor HLA in transplant rejection
This project studies why certain T cells attack transplanted kidneys, with the goal of understanding which cells drive acute rejection and how they recognize donor HLA.
-
Targeted antibody-guided nanoparticles to treat CMV infection
A new treatment approach combines CMV-targeting antibodies with drug-loaded nanoparticles to deliver antiviral medicine directly to infected cells, aiming to improve efficacy and reduce side effects for people with CMV infection.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.