Understanding protein changes in cancer to guide treatment
Clinical translation of a NexGen platform for quantifying protein networks in human biospecimens
['FUNDING_R01'] · FRED HUTCHINSON CANCER CENTER · NIH-11141199
This project helps doctors better understand how cancer drugs work by looking closely at proteins in patient samples.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11141199 on ClinicalTrials.gov |
What this research studies
We are developing advanced tools to measure protein networks in small patient samples, like those taken during biopsies. These tools help us see how cancer cells respond to treatments, especially new anti-cancer drugs. By understanding these protein changes, doctors can make more informed decisions about which treatments might work best for each patient. This work aims to bring these powerful laboratory methods directly into clinical trials to improve cancer care.
Who could benefit from this research
Good fit: This research is relevant for cancer patients, particularly those undergoing treatment with anti-cancer agents, as it aims to improve how their treatment response is monitored.
Not a fit: Patients not currently undergoing cancer treatment or those whose conditions are not targeted by anti-cancer agents may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more personalized and effective cancer treatments by precisely tracking how drugs affect cancer at a molecular level.
How similar studies have performed: The first phase of this partnership successfully optimized the technology, developed necessary procedures, and translated protein assays into clinical trials, indicating a strong foundation for continued work.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PAULOVICH, AMANDA G — FRED HUTCHINSON CANCER CENTER
- Study coordinator: PAULOVICH, AMANDA G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents