Understanding protein changes in brain cells related to aging and Alzheimer's disease
Astrocyte and neuron brain-region and compartment-specific proteome dynamics in aging and Alzheimer’s disease
This study is looking at how certain proteins in brain cells change as we get older and how these changes relate to Alzheimer's disease, with the hope of finding new ways to diagnose and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11101254 on NIH RePORTER |
What this research studies
This research investigates how proteins in astrocytes and neurons change as we age and in the context of Alzheimer's disease (AD). By using advanced techniques to analyze these brain cells together, the study aims to uncover the molecular mechanisms that contribute to AD. The researchers will focus on specific brain regions and the interactions between different cell types to gain insights into the disease's progression. This comprehensive approach could lead to the development of new diagnostics and treatments for AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients with early-stage Alzheimer's disease or those without any cognitive impairment may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel diagnostics and disease-modifying treatments for Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in understanding the roles of astrocytes and neurons in Alzheimer's disease, but this specific approach using proteomic methods is relatively novel.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Khakh, Baljit — University of California Los Angeles
- Study coordinator: Khakh, Baljit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.