Understanding Protein Changes in Alzheimer's Disease
Elucidating the dynamical and structural molecular factors at the origin of non-enzymatic protein-protein and protein-DNA cross-links
This project aims to understand how certain protein and DNA changes happen in the body, which are linked to conditions like Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-11125801 on NIH RePORTER |
What this research studies
Our bodies can experience changes where proteins and DNA get tangled or linked together in ways they shouldn't. These 'cross-links' are connected to many serious health issues, including Alzheimer's disease, but we don't fully understand how they form. This project uses advanced computer models to look closely at these molecular changes. We want to discover the exact structural and movement factors that cause these harmful links, especially those triggered by sugars. By understanding these basic processes, we hope to pave the way for new ways to prevent or treat these diseases.
Who could benefit from this research
Good fit: While this is a basic science project, future clinical applications could benefit patients with conditions like Alzheimer's disease, Parkinson's, or diabetes, where protein and DNA cross-links play a role.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find direct benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could provide fundamental insights into the causes of diseases like Alzheimer's, potentially leading to new strategies for prevention or treatment.
How similar studies have performed: This project addresses a gap in our understanding of cross-link formation, suggesting a novel approach to a poorly understood mechanism.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Vaissier Welborn, Valerie — Virginia Polytechnic Inst and St Univ
- Study coordinator: Vaissier Welborn, Valerie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.