Understanding protective pathways in esophageal cells
Official title: Cytoprotective pathways in esophageal squamous epithelia
Funded at University of Pennsylvania · NIH-11093982 · Data updated 2026-11-12
This study looks at how certain cells in the esophagus protect themselves from becoming cancerous when exposed to harmful things like alcohol and cigarette smoke, focusing on two important proteins that help them stay healthy, which could lead to new ways to prevent esophageal cancer and improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 15, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $516,876 |
| NIH project number | 5R01DK120989-03 |
| Project ID | NIH-11093982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for esophageal cancer, particularly those with a history of alcohol use or smoking.
✕Less likely to help
Patients with esophageal disorders unrelated to cancer or those who do not have risk factors for esophageal cancer may not benefit from this research.
What this research studies
This research investigates how esophageal squamous epithelial cells, which can be damaged by substances like alcohol and cigarette smoke, protect themselves from becoming cancerous. The focus is on two key proteins, KLF5 and p53, which help these cells respond to stress and prevent malignant transformation. By studying these protective mechanisms, the research aims to uncover how normal cells resist cancer development, potentially leading to new prevention strategies. Patients may benefit from insights that could inform future treatments or preventive measures for esophageal cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing esophageal cancer by enhancing the protective mechanisms of esophageal cells.
How similar studies have gone: Previous research has shown success in understanding cytoprotective mechanisms in other types of cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Katz, Jonathan P — University of Pennsylvania
- Study coordinator: Katz, Jonathan P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.