Understanding Protection Against Gut Infections in Children and Adults
Mechanisms of Mucosal and Systemic Immunity to Vaccination and Infection with Enteric Pathogens in Children and Adults
['FUNDING_OTHER'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11173610
This project aims to understand how our bodies protect themselves from serious gut infections like typhoid and shigellosis in both children and adults.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11173610 on ClinicalTrials.gov |
What this research studies
Many children and adults, especially in developing countries, suffer from severe gut infections such as typhoid fever and shigellosis. We don't fully understand how our immune system protects us from these illnesses, which makes it hard to create effective vaccines. This project will look closely at immune responses in the gut and throughout the body using samples from people who have been vaccinated or infected. By focusing on human-specific bacteria, we hope to discover better ways to prevent and treat these common diseases.
Who could benefit from this research
Good fit: This work focuses on understanding immune responses in children aged 0-11 years and adults aged 21 years and older who have been vaccinated or infected with specific gut bacteria.
Not a fit: Patients whose conditions are unrelated to typhoid, invasive non-typhoidal Salmonella, or shigellosis would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of more effective vaccines and treatments for serious gut infections, particularly for children.
How similar studies have performed: Current knowledge about immune protection against these specific human gut infections, especially in children, is limited, making this a novel and much-needed area of focus.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SZTEIN, MARCELO B. — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: SZTEIN, MARCELO B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.