Understanding Prostate Cancer Treatment Resistance
A novel role for EZH2 in PARP regulation and PARPi-resistance in prostate cancer
This project looks for new ways to overcome treatment resistance in men with advanced prostate cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11137614 on NIH RePORTER |
What this research studies
Prostate cancer is a serious illness for many men, and current treatments can have side effects or stop working over time. Our team is exploring why some prostate cancers become resistant to therapies, specifically focusing on a protein called EZH2. We know that high levels of EZH2 are linked to more aggressive cancer and shorter survival. By understanding how EZH2 affects DNA repair and resistance to certain drugs, we hope to find better ways to treat metastatic prostate cancer.
Who could benefit from this research
Good fit: This foundational research is focused on understanding the biology of prostate cancer, particularly in men with advanced or metastatic forms.
Not a fit: Patients with early-stage prostate cancer or those not experiencing treatment resistance may not directly benefit from this specific line of research at this stage.
Why it matters
Potential benefit: If successful, this work could lead to new, more effective treatments for men with advanced prostate cancer, especially those who have developed resistance to current therapies.
How similar studies have performed: This project explores a novel connection between EZH2 and PARP regulation in prostate cancer, building on existing knowledge about EZH2's role in cancer progression and the use of PARP inhibitors.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Cao, Qi — Northwestern University
- Study coordinator: Cao, Qi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.