Understanding prostate cancer risk in diverse populations using advanced genetic analysis
An integrative multi-omics approach to characterize prostate cancer risk in diverse populations
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-10929953
This study is looking at how genes might affect the risk of prostate cancer, especially in men of African descent, to help find out why they get the disease more often and to improve treatment options based on their unique genetic makeup.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-10929953 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors contributing to prostate cancer risk, particularly focusing on men of African ancestry who experience higher rates of this disease. By employing a multi-omics approach, the study aims to integrate various biological data to identify genetic variants that may influence prostate cancer aggressiveness and mortality. The methodology includes analyzing large-scale genetic data alongside other molecular information to uncover new insights into the disease's mechanisms. Patients may benefit from a better understanding of their individual risk factors and more personalized treatment options based on genetic findings.
Who could benefit from this research
Good fit: Ideal candidates for this research include men of African ancestry who are at risk for or have been diagnosed with prostate cancer.
Not a fit: Patients of non-African ancestry or those without a prostate cancer diagnosis may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted therapies for prostate cancer in diverse populations.
How similar studies have performed: Previous research has shown promise in using integrative omics approaches to uncover genetic risk factors in various diseases, suggesting potential success for this novel application in prostate cancer.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MANCUSO, NICHOLAS — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: MANCUSO, NICHOLAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology, Cancer Cause, Cancer Etiology