Understanding prostate cancer in African American men
Official title: Project 1
Funded at Johns Hopkins University · NIH-11012038 · Data updated 2026-11-12
This study is looking at why African American men tend to have more aggressive prostate cancer than non-Latino White men, and it aims to find specific biological markers that could help predict how the disease will progress, all while working to improve health outcomes for these men.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $225,975 |
| NIH project number | 1U54CA295336-01 |
| Project ID | NIH-11012038 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American men diagnosed with locally metastatic prostate cancer.
✕Less likely to help
Patients who do not have prostate cancer or are not of African American descent may not benefit from this research.
What this research studies
This research investigates the biological factors contributing to the higher rates of aggressive prostate cancer in African American men compared to non-Latino White men. By establishing a unique cohort of African American men with locally metastatic prostate cancer, the study aims to perform genomic and epigenomic profiling to identify molecular biomarkers that could predict disease outcomes. The research will also explore differences between primary and metastatic disease, focusing on the immune tumor microenvironment and its role in cancer progression. This collaborative effort between Johns Hopkins University and Howard University seeks to address significant health disparities in cancer outcomes.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted biomarkers that improve diagnosis and treatment for prostate cancer in African American men.
How similar studies have gone: Previous research has shown promising results in identifying biomarkers in prostate cancer, but this specific focus on African American men is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Lotan, Tamara Levin — Johns Hopkins University
- Study coordinator: Lotan, Tamara Levin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.