Understanding Preeclampsia in Pregnancy
Elucidation of the upstream transcription factors controlling preeclampsia-specific gene expression using human trophoblast stem cells as a model system
This research aims to uncover the root causes of preeclampsia, a serious pregnancy complication, by studying how certain genes are controlled in placental cells.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-11179387 on NIH RePORTER |
What this research studies
Preeclampsia is a common and serious pregnancy condition that starts in the placenta, affecting up to 8% of pregnancies. It can lead to high blood pressure, organ damage for the mother, and growth problems or early birth for the baby, with delivery being the only current cure. While we know that problems with placental cell development are key, the exact molecular reasons are still a mystery. This project uses human placental stem cells to find the specific genetic switches that cause preeclampsia, hoping to reveal new ways to prevent or treat it.
Who could benefit from this research
Good fit: This foundational research could eventually benefit pregnant individuals at risk for or experiencing preeclampsia.
Not a fit: Patients not experiencing or at risk for preeclampsia would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to predict, prevent, or treat preeclampsia, improving health outcomes for mothers and babies.
How similar studies have performed: While many genes linked to preeclampsia have been identified, the specific genetic switches driving these changes are not yet well understood, making this a novel approach.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Kim, Jonghwan — University of Texas at Austin
- Study coordinator: Kim, Jonghwan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.