Understanding Pre-Cancer Changes in the Colon
Human Pre-Cancer Models
This work creates and studies models of pre-cancerous colon cells and immune cells to help us learn more about how colon cancer starts.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11176225 on NIH RePORTER |
What this research studies
This project establishes a central resource to grow and study pre-cancerous colon cells, called organoids, from patient samples. Researchers will also isolate specific immune cells, like neutrophils and T cells, from patients to understand their role in early cancer development. These resources will support several related projects, helping scientists explore new ideas and conduct future studies on colon cancer prevention. The goal is to build a comprehensive collection of human colon models with detailed patient information to advance our understanding of pre-cancer.
Who could benefit from this research
Good fit: Patients who have donated colon tissue (normal, pre-cancerous, or cancerous) or blood samples for research may have contributed to the resources used in this work.
Not a fit: Patients seeking immediate treatment for active colon cancer or those not at risk for colon cancer may not directly benefit from this specific foundational research.
Why it matters
Potential benefit: This foundational work could lead to a deeper understanding of how colon cancer develops, potentially paving the way for new ways to prevent or detect it early.
How similar studies have performed: The project leverages existing institutional infrastructure and experience from previous colorectal cancer research, suggesting a solid foundation for this new core facility.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Singh, Bhuminder — Vanderbilt University Medical Center
- Study coordinator: Singh, Bhuminder
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.