Understanding PP2A Changes in Cancer and Brain Disorders
Structural basis of PP2A phosphatase diseases
This research explores how changes in a protein called PP2A contribute to conditions like cancer and certain brain disorders, including Jordan Syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11116925 on NIH RePORTER |
What this research studies
We are looking closely at a protein called PP2A, which plays a key role in how our cells work, to understand how its changes lead to serious conditions like cancer and certain brain disorders. Specifically, we are focusing on how specific changes, or mutations, in PP2A's components, particularly in a part called B56, contribute to intellectual disabilities and cancer. Our team uses advanced techniques like high-resolution imaging and computer simulations to see the exact structure of PP2A and how these mutations alter its function. By understanding these tiny changes, we hope to uncover the root causes of these diseases at a molecular level.
Who could benefit from this research
Good fit: This foundational research is for patients with conditions like cancer and neurological disorders, especially those with known PP2A mutations or Jordan Syndrome, as it aims to understand the underlying causes of their disease.
Not a fit: Patients whose conditions are not related to PP2A protein changes may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose and treat diseases caused by PP2A changes, offering hope for patients with certain cancers and neurological conditions like Jordan Syndrome.
How similar studies have performed: This research builds upon preliminary findings from the research team, indicating a foundation of prior successful work in this area.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Xing, Yongna — University of Wisconsin-Madison
- Study coordinator: Xing, Yongna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.