Understanding pouch inflammation in ulcerative colitis patients after surgery
Characterizing the Biologic Evolution of Crohn's Disease Like Pouch Inflammation in Ulcerative Colitis Patients After Restorative Proctocolectomy with Ileal Pouch Anal Anastomosis
This study is looking at how certain biological changes happen in people with ulcerative colitis after they have a surgery called restorative proctocolectomy, especially for those who might develop inflammation similar to Crohn's disease, to help find better ways to treat and monitor their condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11014984 on NIH RePORTER |
What this research studies
This research investigates the biological changes in patients with ulcerative colitis who undergo a specific surgical procedure called restorative proctocolectomy with ileal pouch anal anastomosis. The study focuses on analyzing genetic variants, microbial profiles, and metabolic changes in these patients, particularly those who develop Crohn’s Disease-like pouch inflammation. By examining these factors, the research aims to identify specific characteristics that may indicate a higher risk for developing this condition. This could help in tailoring more effective treatments and monitoring strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with medically refractory ulcerative colitis who have undergone restorative proctocolectomy with ileal pouch anal anastomosis.
Not a fit: Patients who do not have ulcerative colitis or those who have not undergone the specific surgical procedure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for patients with ulcerative colitis who are at risk of developing pouch inflammation.
How similar studies have performed: Other research has shown promising results in understanding inflammatory bowel diseases through similar biological and genetic analyses, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Kayal, Maia — Icahn School of Medicine at Mount Sinai
- Study coordinator: Kayal, Maia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.