Understanding pouch inflammation in ulcerative colitis patients after surgery
Official title: Characterizing the Biologic Evolution of Crohn's Disease Like Pouch Inflammation in Ulcerative Colitis Patients After Restorative Proctocolectomy with Ileal Pouch Anal Anastomosis
Funded at Icahn School of Medicine at Mount Sinai · NIH-11014984 · Data updated 2026-11-12
This study is looking at how certain biological changes happen in people with ulcerative colitis after they have a surgery called restorative proctocolectomy, especially for those who might develop inflammation similar to Crohn's disease, to help find better ways to treat and monitor their condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $190,904 |
| NIH project number | 5K23DK127241-04 |
| Project ID | NIH-11014984 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with medically refractory ulcerative colitis who have undergone restorative proctocolectomy with ileal pouch anal anastomosis.
✕Less likely to help
Patients who do not have ulcerative colitis or those who have not undergone the specific surgical procedure may not benefit from this research.
What this research studies
This research investigates the biological changes in patients with ulcerative colitis who undergo a specific surgical procedure called restorative proctocolectomy with ileal pouch anal anastomosis. The study focuses on analyzing genetic variants, microbial profiles, and metabolic changes in these patients, particularly those who develop Crohn’s Disease-like pouch inflammation. By examining these factors, the research aims to identify specific characteristics that may indicate a higher risk for developing this condition. This could help in tailoring more effective treatments and monitoring strategies for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for patients with ulcerative colitis who are at risk of developing pouch inflammation.
How similar studies have gone: Other research has shown promising results in understanding inflammatory bowel diseases through similar biological and genetic analyses, indicating that this approach has potential for success.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Kayal, Maia — Icahn School of Medicine at Mount Sinai
- Study coordinator: Kayal, Maia
Related research
Other NIH-funded projects on the same topics.
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Crohn's-like inflammation in the ileal pouch after colon removal for ulcerative colitis
This project looks for genetic, tissue, microbiome, and metabolite patterns linked to Crohn’s-like inflammation in people with ulcerative colitis who had their colon removed and an ileal pouch created.
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Site-specific gene-microbial interactions in children with Crohn’s disease
A child-focused study explores how genes and gut microbes interact in very young children with Crohn’s disease to understand why the disease starts and how it might be treated.
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Ultrasound markers to measure Crohn’s disease activity
A Mayo Clinic team is testing new 3D ultrasound methods to reliably track inflammation and scarring in Crohn’s disease using safe, affordable imaging that could replace more costly scans.
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Outpatient pathway for severe ulcerative colitis in the right care setting
This study tests a safe, outpatient approach using an oral therapy and remote monitoring for people with acute severe ulcerative colitis to avoid hospitalization.
-
Fh15-based therapy to calm inflammation in sepsis and ulcerative colitis
A research project tests a molecule from a parasitic organism (Fh15) to reduce harmful inflammation in adults with sepsis or ulcerative colitis.
-
IMYX-3 treatment for ulcerative colitis
A new therapy approach called IMYX-3 aims to help adults with moderate to severe ulcerative colitis who have not responded well to current treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.