Understanding Platelets and Organ Failure After Severe Injury
The Platelet Transcriptome and Organ Failure After Injury: Discovering Molecular Biomarkers and Preventative Targets through Interrogating Novel RNA Modifications
This research explores how blood platelets change after a severe injury to understand why some patients develop organ failure and how we might prevent it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11143832 on NIH RePORTER |
What this research studies
After a severe injury, many patients survive the initial trauma but later develop serious organ problems. Our team is studying how tiny blood cells called platelets, which are important for clotting, might also play a role in this organ failure. We are looking closely at the genetic material within platelets to see how it changes after an injury. Because platelets don't make new genetic material, they offer a unique window into these early changes in the body. The goal is to find new ways to predict which patients are at highest risk and develop early treatments to prevent organ failure.
Who could benefit from this research
Good fit: This research focuses on patients who have experienced severe injuries and are at risk for developing organ failure.
Not a fit: Patients without severe injuries or those not at risk for organ failure would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify patients at risk for organ failure after injury and develop early treatments to prevent it.
How similar studies have performed: Similar approaches using platelet genetic information have improved understanding in other diseases, suggesting this method holds promise for injury patients.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Kornblith, Lucy Zumwinkle — University of California, San Francisco
- Study coordinator: Kornblith, Lucy Zumwinkle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.