Understanding Platelets and Diabetes to Prevent Heart Attacks and Strokes
Platelet Metabolism in Diabetes Mellitus
['FUNDING_R01'] · UNIVERSITY OF KENTUCKY · NIH-11184175
This research explores how diabetes affects blood platelets, which are tiny cells that help blood clot, to find new ways to prevent heart attacks and strokes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KENTUCKY (nih funded) |
| Locations | 1 site (LEXINGTON, UNITED STATES) |
| Trial ID | NIH-11184175 on ClinicalTrials.gov |
What this research studies
Heart disease and stroke are serious concerns for people with Type 1 diabetes, and high blood sugar levels are a major factor. We know that platelets, which are crucial for stopping bleeding, can become overactive in diabetes, leading to dangerous blood clots. This project aims to uncover exactly how high blood sugar causes platelets to become hyperactive and form clots. By understanding these processes, we hope to develop new treatments that can reduce the risk of heart attacks and strokes for individuals with Type 1 diabetes.
Who could benefit from this research
Good fit: This foundational research is relevant to patients with Type 1 diabetes who are at risk for cardiovascular complications like heart attacks and strokes.
Not a fit: Patients without Type 1 diabetes or those not at risk for diabetes-related cardiovascular events may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new medications or strategies to prevent heart attacks and strokes in people living with Type 1 diabetes.
How similar studies have performed: While the specific 'glycogen-PPP-F1,6BP axis' in platelet metabolism is a novel focus, previous research has established a link between diabetes, platelet hyperactivity, and cardiovascular risk.
Where this research is happening
LEXINGTON, UNITED STATES
- UNIVERSITY OF KENTUCKY — LEXINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, QINGJUN — UNIVERSITY OF KENTUCKY
- Study coordinator: WANG, QINGJUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.