Understanding placental issues in preeclampsia
Official title: Genomic Dissection of Placental Lesions in Preeclampsia
Funded at University of California, San Diego · NIH-10742701 · Data updated 2026-11-12
This study is looking at how certain genetic changes in women with preeclampsia might affect the health of the placenta, which is important for a healthy pregnancy, and it’s designed for those interested in understanding more about this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $426,639 |
| NIH project number | 1R21HD110893-01A1 |
| Project ID | NIH-10742701 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women diagnosed with preeclampsia or those at high risk for developing the condition.
✕Less likely to help
Patients who are not pregnant or those without a diagnosis of preeclampsia may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to placental lesions in women with preeclampsia, a condition that can lead to serious complications during pregnancy. By examining how specific mutations affect the development and function of placental cells, the study aims to uncover the underlying mechanisms of preeclampsia. Researchers will create stem cell lines from human placentas and use advanced gene-editing techniques to simulate the effects of these mutations. This approach will help clarify how these genetic changes impact placental health and fetal development.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of preeclampsia, potentially improving outcomes for mothers and their babies.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in placental development, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Fisch, Kathleen Marie — University of California, San Diego
- Study coordinator: Fisch, Kathleen Marie
Related research
Other NIH-funded projects on the same topics.
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Placental support cells and fetal red blood cell quality in preeclampsia
This grant studies how placental support cells in preeclampsia affect the development and quality of a baby’s red blood cells.
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Epigenetic clues to preeclampsia in pregnancy
This grant explores how epigenetic changes and paternal factors may contribute to preeclampsia, a condition that can affect pregnancy health.
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A digital health approach uses AI to spot early warning signs of preeclampsia and gestational hypertension from pregnancy data, so clinicians can tailor care for pregnant people.
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Folate Receptor Beta and its Role in Preeclampsia
This study explores how a protein called folate receptor beta on placental immune cells may drive or worsen preeclampsia in pregnancy, with hopes of finding new ways to prevent or treat the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.