Understanding placental issues in preeclampsia
Genomic Dissection of Placental Lesions in Preeclampsia
This study is looking at how certain genetic changes in women with preeclampsia might affect the health of the placenta, which is important for a healthy pregnancy, and it’s designed for those interested in understanding more about this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10742701 on NIH RePORTER |
What this research studies
This research investigates the genetic factors contributing to placental lesions in women with preeclampsia, a condition that can lead to serious complications during pregnancy. By examining how specific mutations affect the development and function of placental cells, the study aims to uncover the underlying mechanisms of preeclampsia. Researchers will create stem cell lines from human placentas and use advanced gene-editing techniques to simulate the effects of these mutations. This approach will help clarify how these genetic changes impact placental health and fetal development.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women diagnosed with preeclampsia or those at high risk for developing the condition.
Not a fit: Patients who are not pregnant or those without a diagnosis of preeclampsia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of preeclampsia, potentially improving outcomes for mothers and their babies.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors in placental development, suggesting that this approach may yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Fisch, Kathleen Marie — University of California, San Diego
- Study coordinator: Fisch, Kathleen Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.