Understanding placental injury in women of African ancestry with severe preeclampsia
Official title: Identifying placental injury pathways in women of African ancestry with severe preeclampsia
Funded at University of California, San Diego · NIH-10742342 · Data updated 2026-11-12
This study is looking into why women of African ancestry have more serious problems with severe preeclampsia during pregnancy, focusing on the placenta and how it might be affected, and it hopes to find new ways to help improve their pregnancy outcomes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $434,500 |
| NIH project number | 1R21HD110611-01A1 |
| Project ID | NIH-10742342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women of African ancestry who are experiencing severe preeclampsia.
✕Less likely to help
Patients who are not of African ancestry or who do not have severe preeclampsia may not benefit from this research.
What this research studies
This research investigates the reasons why women of African ancestry experience worse outcomes from severe preeclampsia, a serious pregnancy-related condition. It focuses on the role of the placenta and aims to identify specific cellular and molecular injury pathways that contribute to these adverse outcomes. By examining immunologic processes and genetic factors, the study seeks to uncover potential therapeutic targets that could improve pregnancy outcomes for these women. Patients may be involved in providing samples or data to help understand these mechanisms better.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and better pregnancy outcomes for women of African ancestry suffering from severe preeclampsia.
How similar studies have gone: While the specific focus on placental injury pathways in women of African ancestry is novel, similar research has shown promise in understanding preeclampsia and its varied impacts across different populations.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Aisagbonhi, Omonigho Augustina — University of California, San Diego
- Study coordinator: Aisagbonhi, Omonigho Augustina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.