Understanding Placental Hormones and Gestational Diabetes
Placental Hormones and O-GlcNAcylation in Gestational Diabetes
This work explores how hormones from the placenta and a process called O-GlcNAcylation contribute to gestational diabetes, aiming to find new ways to help mothers and babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11143848 on NIH RePORTER |
What this research studies
We know that gestational diabetes can lead to lasting health problems for both mothers and their children, including type 2 diabetes and heart conditions. This condition progresses quickly during pregnancy, likely due to issues with the placenta. Our goal is to understand how a specific process called O-GlcNAcylation, which is affected by blood sugar levels, influences the placenta's hormone production. By learning more about these connections, we hope to discover new and safer ways to prevent and treat gestational diabetes.
Who could benefit from this research
Good fit: This research is relevant for pregnant individuals who develop or are at risk of developing gestational diabetes.
Not a fit: Patients who are not pregnant or do not have gestational diabetes would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to innovative and non-toxic treatments for gestational diabetes, improving health outcomes for mothers and their children.
How similar studies have performed: While O-GlcNAcylation is known to affect hormone secretion and placental health, its specific role in gestational diabetes development is being investigated for the first time in this project.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Olivier-Van Stichelen, Stephanie — Medical College of Wisconsin
- Study coordinator: Olivier-Van Stichelen, Stephanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.