Understanding PKA Changes in Cushing's Syndrome
Defective PKA Signaling in Cushing's Syndrome
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11146454
This research explores how changes in a protein called PKA contribute to Cushing's syndrome, a condition where the body makes too much stress hormone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11146454 on ClinicalTrials.gov |
What this research studies
Cushing's syndrome happens when your adrenal glands produce too much cortisol, often due to tumors, and it affects women more frequently. This excess cortisol can lead to high blood sugar and blood pressure. Our work looks at the specific genetic changes in a protein called PKA that are common in many patients with Cushing's syndrome. We want to understand how these genetic changes cause the PKA protein to malfunction and lead to the disease.
Who could benefit from this research
Good fit: This research is most relevant to patients with Cushing's syndrome, especially those whose condition is linked to specific genetic changes in the PKA protein.
Not a fit: Patients without Cushing's syndrome or those whose condition is not related to PKA genetic mutations may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of Cushing's syndrome and potentially new ways to treat it by targeting these specific protein changes.
How similar studies have performed: Advances in precision medicine have already identified the genetic mutations being studied, suggesting a foundation of existing knowledge in this area.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCOTT, JOHN D — UNIVERSITY OF WASHINGTON
- Study coordinator: SCOTT, JOHN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.