Understanding pediatric sepsis to improve diagnosis and treatment
Resubmission: Elucidating Pediatric Sepsis by Defining Comprehensive Signatures for Diagnosis and Outcome
This study is looking at how to better recognize and treat pediatric sepsis in kids by finding special signs in their blood and immune responses, so doctors can act quickly and help them recover faster.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10919229 on NIH RePORTER |
What this research studies
This research investigates pediatric sepsis, a severe condition caused by infections that can lead to organ failure in children. The team aims to identify unique biological signatures in children presenting with sepsis in emergency departments, using a combination of vital signs, laboratory tests, and advanced techniques to analyze immune responses at the cellular level. By understanding these signatures, the goal is to enhance the speed and accuracy of sepsis diagnosis, allowing for timely and appropriate treatment to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-18 years who present with symptoms of sepsis in emergency departments.
Not a fit: Patients who do not exhibit symptoms of sepsis or are outside the age range of 0-18 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce morbidity and mortality rates associated with pediatric sepsis by enabling faster and more accurate diagnoses.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for sepsis, but this approach aims to provide a more comprehensive understanding of pediatric sepsis, making it a novel endeavor.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Mahajan, Prashant — University of Michigan at Ann Arbor
- Study coordinator: Mahajan, Prashant
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.