Understanding Pancreatic Cell Health in Diabetes
Regulation of pancreatic islet cell fate
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11128534
This research explores how pancreatic cells, especially those making insulin, develop and stay healthy, which is key for people with Type 1 and Type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11128534 on ClinicalTrials.gov |
What this research studies
This project aims to understand why insulin-producing cells in the pancreas are lost in diabetes and how to create better ones from stem cells. Researchers are working to identify the precise genetic and cellular signals that guide these cells to become and remain fully functional. The goal is to improve methods for making healthy pancreatic cells from human stem cells, which could eventually lead to new treatments for diabetes. This work also looks at why these important cells sometimes lose their identity and stop working properly under disease conditions.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals with Type 1 and Type 2 diabetes in the future.
Not a fit: Patients seeking immediate treatment or direct participation in a clinical trial would not find direct benefit from this basic science grant.
Why it matters
Potential benefit: If successful, this work could lead to new ways to produce healthy, functional insulin-producing cells, offering potential future therapies for Type 1 and Type 2 diabetes.
How similar studies have performed: While progress has been made in using stem cells to create islet cells, the efficient production of pure, fully functional beta cells is still a challenge, indicating this work builds on existing efforts but addresses current limitations.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUSSEL, LORI — UNIVERSITY OF COLORADO DENVER
- Study coordinator: SUSSEL, LORI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.