Understanding pain mechanisms in Fabry Disease
Pain Mechanisms in Fabry Disease
This study is looking into how Fabry Disease causes pain and sensitivity in nerves, using a special rat model to find new ways to help manage pain for people living with this condition.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11061919 on NIH RePORTER |
What this research studies
This research investigates the cellular mechanisms that cause pain and hypersensitivity in patients with Fabry Disease, a genetic condition that affects the body's ability to break down certain fats. By using a specially designed rat model that mimics the disease, researchers aim to uncover how the accumulation of specific substances in nerve cells leads to pain. The study focuses on identifying new targets for pain treatment, which could lead to better management strategies for those suffering from this condition. Patients may experience episodic and chronic pain, and this research seeks to improve their quality of life through innovative therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fabry Disease who experience pain or hypersensitivity.
Not a fit: Patients without Fabry Disease or those who do not experience pain related to the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new and more effective pain management options for patients with Fabry Disease.
How similar studies have performed: Previous research has shown promise in understanding pain mechanisms in other conditions, suggesting that this approach could yield valuable insights for Fabry Disease as well.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Stucky, Cheryl Louise — Medical College of Wisconsin
- Study coordinator: Stucky, Cheryl Louise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.