Understanding pain mechanisms in Fabry Disease
Official title: Pain Mechanisms in Fabry Disease
Funded at Medical College of Wisconsin · NIH-11061919 · Data updated 2026-11-12
This study is looking into how Fabry Disease causes pain and sensitivity in nerves, using a special rat model to find new ways to help manage pain for people living with this condition.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | May 15, 2019 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $857,423 |
| NIH project number | 5R37NS108278-07 |
| Project ID | NIH-11061919 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Fabry Disease who experience pain or hypersensitivity.
✕Less likely to help
Patients without Fabry Disease or those who do not experience pain related to the condition may not benefit from this research.
What this research studies
This research investigates the cellular mechanisms that cause pain and hypersensitivity in patients with Fabry Disease, a genetic condition that affects the body's ability to break down certain fats. By using a specially designed rat model that mimics the disease, researchers aim to uncover how the accumulation of specific substances in nerve cells leads to pain. The study focuses on identifying new targets for pain treatment, which could lead to better management strategies for those suffering from this condition. Patients may experience episodic and chronic pain, and this research seeks to improve their quality of life through innovative therapies.
Why it matters
Potential benefit: If successful, this research could lead to new and more effective pain management options for patients with Fabry Disease.
How similar studies have gone: Previous research has shown promise in understanding pain mechanisms in other conditions, suggesting that this approach could yield valuable insights for Fabry Disease as well.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Stucky, Cheryl Louise — Medical College of Wisconsin
- Study coordinator: Stucky, Cheryl Louise
Related research
Other NIH-funded projects on the same topics.
-
Understanding pain mechanisms in Fabry disease
This study is looking at how pain works in people with Fabry disease by using rats to understand why some nerve cells get too sensitive and cause pain, especially when it’s hot, which could help find new ways to relieve pain for those living with this condition.
-
Testing a new enzyme therapy for Fabry disease
This study is looking at a new way to give enzyme therapy for Fabry disease that involves a simple shot under the skin, making it easier and less painful for patients compared to regular IV treatments.
-
New urine tests to assess kidney health in Fabry disease
This study is working on a simple urine test to help people with Fabry disease check for kidney damage by looking at important kidney cells and a specific substance, so they can get better care and treatment sooner.
-
Lucerastat in untreated adult men with Fabry disease shows how well it works and safety
This study tests lucerastat to see if it can reduce Gb3 buildup and be safe in untreated adult men with Fabry disease.
-
Periodontal Health in Rare Kidney Conditions and Controls
This study tests how common periodontitis is in people with rare kidney disorders and compares it to CKD patients and people without kidney disease.
-
Anderson-Fabry disease fitness improvement program
This study tests whether a 12-week physiotherapy-led exercise program can improve function, fitness, strength, and quality of life in adults with Fabry disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.