Understanding pain mechanisms in Fabry disease
Official title: Mechanisms of Neuronal Excitability and Pain in Fabry Disease
Funded at Medical College of Wisconsin · NIH-10947214 · Data updated 2026-11-12
This study is looking at how pain works in people with Fabry disease by using rats to understand why some nerve cells get too sensitive and cause pain, especially when it’s hot, which could help find new ways to relieve pain for those living with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $73,828 |
| NIH project number | 1F32NS138223-01 |
| Project ID | NIH-10947214 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Fabry disease who experience neuropathic pain.
✕Less likely to help
Patients without Fabry disease or those who do not experience neuropathic pain may not benefit from this research.
What this research studies
This research investigates the underlying mechanisms of pain in patients with Fabry disease, a genetic disorder that leads to painful neuropathy. By using a rat model, the study aims to explore how certain neurons become overly excitable and contribute to pain, especially during heat-induced crises. The researchers will focus on specific sodium channels that may be involved in this process, providing insights into potential therapeutic targets for pain relief in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate pain for patients suffering from Fabry disease.
How similar studies have gone: Previous research has shown success in understanding pain mechanisms in other neuropathic conditions, suggesting potential for breakthroughs in Fabry disease as well.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Enders, Jonathan David — Medical College of Wisconsin
- Study coordinator: Enders, Jonathan David
Related research
Other NIH-funded projects on the same topics.
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This study is looking into how Fabry Disease causes pain and sensitivity in nerves, using a special rat model to find new ways to help manage pain for people living with this condition.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.