Understanding pain mechanisms in Fabry disease
Mechanisms of Neuronal Excitability and Pain in Fabry Disease
This study is looking at how pain works in people with Fabry disease by using rats to understand why some nerve cells get too sensitive and cause pain, especially when it’s hot, which could help find new ways to relieve pain for those living with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10947214 on NIH RePORTER |
What this research studies
This research investigates the underlying mechanisms of pain in patients with Fabry disease, a genetic disorder that leads to painful neuropathy. By using a rat model, the study aims to explore how certain neurons become overly excitable and contribute to pain, especially during heat-induced crises. The researchers will focus on specific sodium channels that may be involved in this process, providing insights into potential therapeutic targets for pain relief in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fabry disease who experience neuropathic pain.
Not a fit: Patients without Fabry disease or those who do not experience neuropathic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate pain for patients suffering from Fabry disease.
How similar studies have performed: Previous research has shown success in understanding pain mechanisms in other neuropathic conditions, suggesting potential for breakthroughs in Fabry disease as well.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Enders, Jonathan David — Medical College of Wisconsin
- Study coordinator: Enders, Jonathan David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.