Understanding pain in women with breast cancer and low estrogen levels
Omics of Pain in the Context of Declining Estrogen
This study is looking at why some women with early-stage breast cancer experience ongoing pain in their muscles and joints while they are getting treatment that lowers estrogen, and it hopes to find ways to help manage that pain better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10892953 on NIH RePORTER |
What this research studies
This research investigates chronic musculoskeletal pain (MSKP) experienced by women with hormone receptor-positive early-stage breast cancer who are undergoing treatment that reduces estrogen levels. The study aims to explore the molecular mechanisms behind this pain by analyzing RNA and DNA samples from participants. By examining how declining estrogen affects pain pathways, the research seeks to identify potential genetic and biological factors that contribute to MSKP. This could lead to better pain management strategies for affected women.
Who could benefit from this research
Good fit: Ideal candidates for this research are postmenopausal women who have been newly diagnosed with early-stage hormone receptor-positive breast cancer and are receiving aromatase inhibitors.
Not a fit: Patients who are not postmenopausal or those who do not have hormone receptor-positive breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic pain in women undergoing breast cancer therapy.
How similar studies have performed: Previous research has shown promising results in understanding pain mechanisms related to hormonal changes, indicating that this approach may yield valuable insights.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Wagner, Monica Ann — Case Western Reserve University
- Study coordinator: Wagner, Monica Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.