Understanding pain in sickle cell disease through gene analysis
Transcriptomics of Pain in Sickle Cell Disease
This study is looking at how genes might affect pain in people with sickle cell disease, and by examining blood samples during different pain episodes, researchers hope to find new ways to help manage that pain better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10901983 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to pain in patients with sickle cell disease (SCD). By analyzing RNA from specific blood cells of SCD patients, the study aims to identify changes in gene expression associated with acute pain events and chronic pain development. The researchers will collect samples during different pain states and use advanced sequencing techniques to uncover potential biomarkers for pain. The ultimate goal is to develop targeted therapies based on these findings to improve pain management for SCD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have been diagnosed with sickle cell disease and experience acute or chronic pain.
Not a fit: Patients who do not have sickle cell disease or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain management strategies for patients with sickle cell disease.
How similar studies have performed: Previous research has shown promise in using genetic analysis to understand pain mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Sheehan, Vivien Andrea — Emory University
- Study coordinator: Sheehan, Vivien Andrea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.