Understanding pain in children with early onset psychosis
Official title: Neurobiological Underpinnings of Pain-Related Symptoms in Early Onset Psychosis
Funded at Boston Children's Hospital · NIH-10741010 · Data updated 2026-11-12
This study is looking at how children with early onset psychosis experience pain, even when doctors can't find a clear reason for it, and it aims to understand their pain better by comparing their experiences with those of healthy kids.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 7, 2023 |
| Project end | July 6, 2025 |
| Funding year | 2023 |
| Award (this year) | $486,750 |
| NIH project number | 1R21MH131941-01A1 |
| Project ID | NIH-10741010 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 13-18 years who have been diagnosed with early onset psychosis.
✕Less likely to help
Patients who do not have early onset psychosis or are outside the age range of 13-18 years may not benefit from this research.
What this research studies
This research investigates the pain experiences of children diagnosed with early onset psychosis (EOP), who often report significant pain without clear medical explanations. The study will assess pain severity and quality, as well as mental health factors, through clinical questionnaires administered to both EOP patients and healthy controls. Additionally, it aims to explore the neurobiological aspects of pain perception in these patients, providing insights into how their nervous systems process pain during critical developmental stages.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of pain in children with early onset psychosis, enhancing their quality of life.
How similar studies have gone: Previous research has shown that understanding pain perception in adults with psychosis can lead to better treatment strategies, suggesting potential for success in this novel approach with children.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Upadhyay, Jaymin a — Boston Children's Hospital
- Study coordinator: Upadhyay, Jaymin a
Related research
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Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
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Computational analysis of facial expression in early psychosis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.