Understanding p53 Gene Changes and Cancer Risk
Functional Analysis of p53 Polymorphic Variants
['FUNDING_R01'] · WISTAR INSTITUTE · NIH-11210456
This research explores how specific changes in the p53 gene, common in people of African descent, might increase cancer risk and how we can find better treatments for them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WISTAR INSTITUTE (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11210456 on ClinicalTrials.gov |
What this research studies
Our bodies have a gene called p53 that helps protect against cancer, but some people have natural variations in this gene. This project looks closely at a specific p53 gene change, called Pro47Ser, which is found in many individuals of African descent and is linked to a higher chance of developing cancer. We aim to understand how this particular gene change affects the body's ability to fight cancer and how it might influence the effectiveness of current cancer treatments. By studying these genetic differences, we hope to discover new ways to prevent cancer or develop more effective therapies tailored to those with this specific p53 variant.
Who could benefit from this research
Good fit: This research is particularly relevant for individuals of African descent who carry the Pro47Ser p53 gene variant, as it aims to understand and address their specific cancer risks and treatment needs.
Not a fit: Patients without the specific Pro47Ser p53 gene variant or those whose cancer is not linked to p53 function may not directly benefit from this particular line of research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify individuals at higher cancer risk and develop more effective, personalized cancer treatments for those with specific p53 gene changes.
How similar studies have performed: This is a long-standing, renewed research effort, indicating a history of successful findings that support continued investigation into p53's role in cancer.
Where this research is happening
PHILADELPHIA, UNITED STATES
- WISTAR INSTITUTE — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MURPHY, MAUREEN E. — WISTAR INSTITUTE
- Study coordinator: MURPHY, MAUREEN E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.