Understanding P. vivax malaria relapses and testing a treatment
Rigorous Assessment of P. vivax Relapses and Primaquine Efficacy for Radical Cure
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10867358
This study is looking at how often the malaria parasite Plasmodium vivax causes relapses in people in Cambodia and what might trigger those relapses, while also testing different doses of a medicine called primaquine to find the best way to treat this type of malaria.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10867358 on ClinicalTrials.gov |
What this research studies
This research investigates the malaria parasite Plasmodium vivax, which can remain dormant in the liver and cause relapses. The study will take place in Cambodia and aims to assess how often these relapses occur and what factors trigger them. Additionally, it will evaluate the effectiveness of different doses of primaquine, a medication used for treatment, to find the best approach for curing this type of malaria. By using advanced genomic analyses, the research seeks to provide insights that could improve malaria elimination efforts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in malaria-endemic regions, particularly those who have experienced P. vivax infections.
Not a fit: Patients who do not have P. vivax malaria or those living outside of endemic regions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for P. vivax malaria, reducing the risk of relapses and improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding malaria treatment, but this specific approach to P. vivax is relatively novel.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SERRE, DAVID — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: SERRE, DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.