Understanding Ovarian Cancer Development from the Fallopian Tube
Dynamic Interactions of the Ovarian-Fallopian Axis in High Grade Serous Ovarian Cancer
['FUNDING_R01'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-11136512
This project explores how the ovary and fallopian tube interact to cause high-grade serous ovarian cancer, the most common and deadly type.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-11136512 on ClinicalTrials.gov |
What this research studies
This research looks into why ovarian cancer, which often starts in the fallopian tubes, frequently grows in the ovary. We are using advanced 3D models that mimic the human menstrual cycle to understand how ovulation might contribute to cancer development. By studying these interactions, we hope to discover how preventing ovulation could stop cancer from forming in the fallopian tubes and spreading to the ovary. This work aims to uncover new ways to prevent this aggressive cancer.
Who could benefit from this research
Good fit: Patients at risk for high-grade serous ovarian cancer, or those interested in understanding its origins, may find this research relevant.
Not a fit: Patients currently undergoing treatment for advanced ovarian cancer may not directly benefit from this foundational prevention research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing high-grade serous ovarian cancer by understanding how to block its initiation and spread.
How similar studies have performed: This project builds on successful prior work developing 3D organotypic cultures and microfluidic platforms that mimic the human reproductive cycle.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BURDETTE, JOANNA E — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: BURDETTE, JOANNA E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.