Understanding Ovarian Cancer Cells That Resist Chemotherapy
Official title: Evaluating unique aspects of quiescent ovarian cancer cell biology for therapeutic targets
Funded at Magee-Women's Res Inst and Foundation · NIH-11110504 · Data updated 2026-11-12
This project aims to discover new ways to treat ovarian cancer by understanding why some cancer cells survive chemotherapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Magee-Women's Res Inst and Foundation NIH-funded |
| Lab location | 1 site (Pittsburgh, UNITED STATES) |
| Project start | July 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $435,361 |
| NIH project number | 5R01CA278100-03 |
| Project ID | NIH-11110504 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have or may develop chemotherapy-resistant ovarian cancer could potentially benefit from future treatments developed from this research.
✕Less likely to help
Patients without ovarian cancer or those whose cancer responds well to current treatments may not directly benefit from this specific research.
What this research studies
Many ovarian cancer patients face a difficult challenge when their cancer returns and no longer responds to chemotherapy. This happens because some cancer cells can go into a "sleepy" state, called quiescence, which makes them resistant to standard treatments that target fast-growing cells. We are exploring the unique features of these quiescent ovarian cancer cells to find new weaknesses. Our goal is to identify new targets that could lead to more effective treatments for relapsed ovarian cancer.
Why it matters
Potential benefit: If successful, this work could lead to the development of new medications that prevent or treat ovarian cancer that has become resistant to chemotherapy.
How similar studies have gone: This project uses novel approaches to explore an understudied mechanism of chemotherapy resistance in ovarian cancer.
Where this research is happening
-
Magee-Women's Res Inst and Foundation
Pittsburgh, United States Active
Researchers
- Principal investigator: Buckanovich, Ronald J — Magee-Women's Res Inst and Foundation
- Study coordinator: Buckanovich, Ronald J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.