Understanding oral health issues in individuals with Down syndrome
Molecular mechanisms of oral deficiencies in Down syndrome
This study is looking at how a gene related to Down syndrome might affect saliva and tooth enamel, which can lead to oral health issues, and it's being done to help improve dental care for people with Down syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10658410 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind oral health problems in individuals with Down syndrome, focusing on issues like poor saliva production and enamel defects. The study aims to explore how a specific gene on chromosome 21, known as RCAN1, affects the formation of salivary glands and tooth enamel. By using a mouse model of Down syndrome, researchers will analyze how these factors contribute to the oral anomalies observed in patients. The findings could lead to better understanding and potential treatments for oral health challenges faced by those with Down syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Down syndrome who experience oral health issues.
Not a fit: Patients without Down syndrome or those who do not have oral health problems related to their condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve oral health outcomes and quality of life for individuals with Down syndrome.
How similar studies have performed: While the specific molecular mechanisms in Down syndrome are not extensively studied, similar research approaches have shown promise in understanding genetic influences on oral health.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Lacruz, Rodrigo S. — New York University
- Study coordinator: Lacruz, Rodrigo S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.