Understanding OAT1's Role in Kidney Disease
The Role in OAT1 in Uremia
This project explores how a key kidney protein called OAT1 helps remove waste and drugs, and how its function changes in kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11159653 on NIH RePORTER |
What this research studies
Our kidneys have a special protein called OAT1 that helps remove waste products from the body, including certain medications and substances from gut microbes. This protein is very important for keeping your body's metabolism balanced. We are looking into how OAT1 works and what happens when it doesn't function properly, especially in people with chronic kidney disease. We believe that problems with OAT1 contribute to the metabolic issues seen in kidney disease.
Who could benefit from this research
Good fit: Patients with chronic kidney disease who experience metabolic imbalances may eventually benefit from this research.
Not a fit: Patients without kidney disease or related metabolic issues may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: If successful, this work could lead to new ways to understand and treat the metabolic complications of chronic kidney disease.
How similar studies have performed: Previous studies, including some in humans, have shown that OAT1 is important for kidney function and overall metabolism, suggesting this approach builds on existing knowledge.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Nigam, Sanjay K — University of California, San Diego
- Study coordinator: Nigam, Sanjay K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.