Understanding nighttime blood pressure patterns in children with kidney disease
Official title: Investigating the Significance of Nocturnal Blood Pressure Patterns in Children with Chronic Kidney Disease
Funded at Yale University · NIH-10846855 · Data updated 2026-11-12
This study looks at how kids with chronic kidney disease experience changes in their blood pressure at night, hoping to find out what might put them at risk for more serious kidney or heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $190,554 |
| NIH project number | 5K23DK129836-05 |
| Project ID | NIH-10846855 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-21 years who have been diagnosed with chronic kidney disease.
✕Less likely to help
Patients without chronic kidney disease or those outside the age range of 0-21 years may not benefit from this research.
What this research studies
This research investigates how blood pressure patterns during the night affect children with chronic kidney disease (CKD). The study uses ambulatory blood pressure monitoring to gather data on blood pressure changes throughout the day and night. By analyzing this data, the researchers aim to identify risk factors that could lead to more severe kidney issues or cardiovascular problems in these children. The project also focuses on training the principal investigator in advanced research methods and clinical trial design.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for blood pressure in children with CKD, potentially reducing their risk of cardiovascular disease.
How similar studies have gone: Previous research has shown that monitoring blood pressure patterns can provide valuable insights into cardiovascular risks in adults, suggesting potential success in pediatric populations as well.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Bakhoum, Christine — Yale University
- Study coordinator: Bakhoum, Christine
Related research
Other NIH-funded projects on the same topics.
-
Breathing Exercises to Lower Blood Pressure in Adults with Kidney Disease
This project explores whether a special type of breathing exercise can help midlife and older adults with chronic kidney disease manage their high blood pressure.
-
Strength training for improving blood pressure in older adults with kidney disease
This study is looking at whether a special breathing exercise using a handheld device can help lower blood pressure in midlife and older adults with chronic kidney disease, making it easier for them to stick with this kind of exercise compared to regular workouts.
-
Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
-
Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
-
Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
-
Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.