Understanding Neutrophil Behavior in Inflammatory Conditions
Neutrophil Survival and Demise During Inflammatory States
This work explores how certain immune cells called neutrophils contribute to inflammation in heart and blood vessel diseases, like heart attacks and strokes.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11187037 on NIH RePORTER |
What this research studies
Our bodies' immune cells, called neutrophils, play a big role in inflammation, especially in conditions like heart disease and stroke. We know that too much inflammation from molecules like Interleukin-1 (IL-1a/b) can lead to serious health problems. This project aims to understand exactly how neutrophils produce these inflammatory molecules and how their life and death cycles affect these diseases. By learning more about these processes, we hope to find new ways to help people with inflammatory cardiovascular conditions.
Who could benefit from this research
Good fit: This foundational research focuses on the underlying biology of cardiovascular disease, so it is relevant to patients with conditions like coronary artery disease, myocardial infarction, and stroke.
Not a fit: Patients without inflammatory cardiovascular conditions or those whose conditions are not driven by neutrophil-mediated inflammation may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target inflammation caused by neutrophils, potentially preventing or improving outcomes for cardiovascular diseases.
How similar studies have performed: While the role of inflammation in cardiovascular disease is recognized, this particular approach seeks a more comprehensive understanding of neutrophil cell death pathways, which is a less explored area.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Hoffman, Harold M — Scripps Research Institute, the
- Study coordinator: Hoffman, Harold M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.