Understanding neuropsychiatric symptoms in Alzheimer's disease using advanced imaging and computational methods
Official title: Combining Computational Methods, RDoC, and Big Neuroimaging Data to Understand Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Disease
Funded at Mclean Hospital · NIH-10500666 · Data updated 2026-11-12
This study is looking at how changes in the brain might cause symptoms like anxiety and aggression in people with Alzheimer's disease, using special brain scans to help find better treatments for these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project start | September 30, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $2,432,945 |
| NIH project number | 1RF1AG078304-01 |
| Project ID | NIH-10500666 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who are experiencing neuropsychiatric symptoms such as anxiety, aggression, or agitation.
✕Less likely to help
Patients without a diagnosis of Alzheimer's disease or those not exhibiting neuropsychiatric symptoms may not benefit from this research.
What this research studies
This research investigates the mechanisms behind neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD), which affect a significant number of patients. By utilizing advanced neuroimaging techniques and computational methods, the study aims to explore how neurodegeneration in specific brain regions correlates with the emergence of symptoms like anxiety and aggression. The research employs a framework that links brain circuit dysfunction to the clinical presentation of NPS, potentially leading to better-targeted treatments. Patients may be monitored through functional MRI to assess brain activity and connectivity related to their symptoms.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for neuropsychiatric symptoms in Alzheimer's patients.
How similar studies have gone: Previous research has shown promising results in understanding neuropsychiatric symptoms through neuroimaging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mclean Hospital
Belmont, United States Active
Researchers
- Principal investigator: Nickerson, Lisa D — Mclean Hospital
- Study coordinator: Nickerson, Lisa D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.