Understanding neuropsychiatric symptoms in Alzheimer's disease
A Proteomic and Genomic Approach to Understanding Neuropsychiatric Symptoms in Alzheimer's Disease
This study is looking at how certain brain changes might cause symptoms like hallucinations and delusions in people with Alzheimer's, and it wants to see if there are differences between men and women to help find better treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10897949 on NIH RePORTER |
What this research studies
This research investigates the neuropsychiatric symptoms, such as hallucinations and delusions, experienced by patients with Alzheimer's disease. It explores the relationship between protein aggregation in the brain and these symptoms, particularly focusing on differences between male and female patients. By analyzing postmortem brain samples, the study aims to identify specific genes and proteins that may contribute to these symptoms and their onset. The approach combines proteomic and genomic techniques to uncover underlying cellular processes that could lead to better understanding and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, particularly those exhibiting neuropsychiatric symptoms.
Not a fit: Patients without a diagnosis of Alzheimer's disease or those not experiencing neuropsychiatric symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for neuropsychiatric symptoms in Alzheimer's patients.
How similar studies have performed: Other research has shown promising results in understanding the link between protein aggregation and neuropsychiatric symptoms in related conditions, suggesting potential for success in this area.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Nucifora, Leslie Giselle — Johns Hopkins University
- Study coordinator: Nucifora, Leslie Giselle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.