Understanding neurodevelopment in adolescents with 22q11.2 deletion syndrome
Official title: 2/2 - Neurodevelopmental Trajectories in 22q11.2 Deletion Syndrome in Adolescence and Young Adulthood
Funded at Children's Hosp of Philadelphia · NIH-11034102 · Data updated 2026-11-12
This study is looking at how 22q11.2 deletion syndrome affects teenagers and young adults, especially in relation to conditions like ADHD, anxiety, and autism, to help understand the challenges they face and how both genes and their surroundings play a role in their development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 13, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $411,666 |
| NIH project number | 5R01MH134965-02 |
| Project ID | NIH-11034102 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents and young adults aged 12 to 20 who have been diagnosed with 22q11.2 deletion syndrome.
✕Less likely to help
Patients who do not have 22q11.2 deletion syndrome or are outside the age range of 12 to 20 may not benefit from this research.
What this research studies
This research investigates how 22q11.2 deletion syndrome affects the development of adolescents and young adults, particularly focusing on neuropsychiatric disorders such as ADHD, anxiety, and autism. By examining the interplay between genetic factors and environmental influences, the study aims to identify common risk mechanisms that contribute to these conditions. Participants will be assessed over time to track their developmental trajectories, providing insights into the unique challenges faced by individuals with this syndrome. The research employs a comprehensive approach that includes both genetic and environmental assessments to better understand the complexities of 22q11.2 deletion syndrome.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of neuropsychiatric disorders in individuals with 22q11.2 deletion syndrome.
How similar studies have gone: Previous research has shown success in understanding neurodevelopmental trajectories in similar genetic syndromes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Mcdonald-Mcginn, Donna Marie — Children's Hosp of Philadelphia
- Study coordinator: Mcdonald-Mcginn, Donna Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.