Understanding neurodegeneration in Alzheimer's and related dementias
"What is N?" Towards operationalizing neurodegeneration in Alzheimer's and related dementias
This study is looking at certain markers in the brain and body that might help us understand and predict memory and thinking changes in people with Alzheimer's and similar conditions, using information from the Mayo Clinic to improve care for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11051265 on NIH RePORTER |
What this research studies
This research investigates neurodegeneration markers (N markers) that are linked to cognitive decline in Alzheimer's disease and related dementias. By analyzing various methods of measuring these markers, including imaging, cerebrospinal fluid (CSF), and blood tests, the study aims to identify how well these markers can predict cognitive outcomes. The research utilizes data from the Mayo Clinic Study of Aging, which includes comprehensive assessments of participants' cognitive and neurological health over time. The goal is to enhance the use of N markers in clinical settings and trials to improve patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, particularly those undergoing cognitive assessments.
Not a fit: Patients with other forms of dementia not related to Alzheimer's or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment strategies for patients with Alzheimer's and related dementias.
How similar studies have performed: Previous research has shown promise in using neurodegeneration markers for predicting cognitive decline, indicating that this approach has potential for success.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Graff-Radford, Jonathan — Mayo Clinic Rochester
- Study coordinator: Graff-Radford, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.