Understanding nerve cell development in the adult intestine
Characterizing neurogenic progenitors in the adult intestine
This study is looking at how certain cells in the adult intestine can turn into nerve cells and help heal inflammation, which could lead to new treatments for gut issues like gastroparesis and Hirschsprung disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11039953 on NIH RePORTER |
What this research studies
This research investigates how nerve cells in the adult intestine can regenerate and respond to inflammation, which is crucial for treating gastrointestinal disorders. The study focuses on specific cells in the gut that have the potential to become nerve cells and how they can be stimulated to do so. By analyzing gene expression and cellular signals, the researchers aim to uncover the mechanisms that control this process, which could lead to new therapies for conditions like gastroparesis and Hirschsprung disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults suffering from gastrointestinal disorders related to nerve function, such as gastroparesis or Hirschsprung disease.
Not a fit: Patients with gastrointestinal disorders not related to nerve function or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for serious gastrointestinal disorders by harnessing the body's own ability to regenerate nerve cells.
How similar studies have performed: Previous research has shown promise in similar approaches to stimulate nerve regeneration in other contexts, indicating potential for success in this area as well.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Goldstein, Allan M — Massachusetts General Hospital
- Study coordinator: Goldstein, Allan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.