Understanding MYH7 Gene Changes in Heart Conditions
Broadly applicable high throughput variant interpretation and validation for MYH7
This project aims to improve how we understand genetic changes in the MYH7 gene, which are linked to heart muscle conditions, using advanced technology.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11097358 on NIH RePORTER |
What this research studies
Our genes contain instructions for our bodies, and sometimes small changes, called variants, can lead to health problems like heart conditions. This project focuses on the MYH7 gene, which is important for heart muscle function. We are developing new ways to quickly and accurately figure out if a specific MYH7 gene change is harmful. This involves using advanced lab techniques with heart cells grown from stem cells and applying artificial intelligence to analyze the results. Our goal is to better understand how these gene changes affect heart cells and lead to disease.
Who could benefit from this research
Good fit: This foundational work is for patients with MYH7-related heart conditions or other genetic diseases who may benefit from improved variant interpretation in the future.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not receive direct benefit from this laboratory-based research.
Why it matters
Potential benefit: If successful, this work could lead to faster and more accurate diagnoses for patients with MYH7-related heart conditions and potentially other genetic diseases.
How similar studies have performed: While AI-assisted variant interpretation is an emerging field, this approach is innovative in its use of single-cell sequencing and machine learning for high-throughput molecular phenotyping of MYH7 variants.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Zhang, Lilei — Baylor College of Medicine
- Study coordinator: Zhang, Lilei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.