Understanding mutations that may lead to blood cancers
Pre-malignant mutation landscape and risk factors for progression to hematologic cancers
This study is looking at blood samples from healthy women to see if certain genetic changes could mean a higher chance of developing blood cancers like leukemia, with the hope of finding ways to better understand and prevent these cancers in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11061356 on NIH RePORTER |
What this research studies
This research investigates the presence of specific mutations in the blood of healthy individuals that may indicate a higher risk of developing hematologic cancers, such as acute myeloid leukemia. By analyzing blood samples from participants in the Women's Health Initiative, the study aims to identify both genetic and environmental factors that contribute to the progression from benign mutations to cancer. The goal is to enhance risk assessment and potentially guide future prevention strategies for at-risk individuals. Participants will be monitored over time to track the evolution of these mutations and their impact on health.
Who could benefit from this research
Good fit: Ideal candidates for this research include healthy individuals with a family history of hematologic cancers or those who have been identified with clonal hematopoiesis.
Not a fit: Patients currently diagnosed with hematologic malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and preventive strategies for individuals at high risk of developing blood cancers.
How similar studies have performed: Previous studies have shown that identifying mutations in blood can significantly improve risk prediction for hematologic cancers, suggesting this approach has potential for success.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Desai, Pinkal — Weill Medical Coll of Cornell Univ
- Study coordinator: Desai, Pinkal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.