Understanding mutations in B-cell cancers
Investigating and modeling MYD88L265P and co-occurring mutations in mature B-cell malignancies
This study is looking at a specific gene change called MYD88L265P to see how it affects different blood cancers, especially Non-Hodgkin lymphomas, and aims to find new treatment options for patients with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10877974 on NIH RePORTER |
What this research studies
This research investigates the MYD88L265P mutation and its role in various types of B-cell malignancies, particularly Non-Hodgkin lymphomas. By using genetically modified mice, the study aims to explore how this mutation contributes to cancer development and progression. The researchers will analyze the differences in behavior between normal and mutated proteins to better understand their impact on cancer cell survival and growth. This work could lead to new insights into targeted therapies for patients with these types of cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with B-cell malignancies, particularly those with the MYD88L265P mutation.
Not a fit: Patients with B-cell malignancies that do not involve the MYD88L265P mutation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with B-cell malignancies.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic mutations in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Carrasco, Ruben D — Dana-Farber Cancer Inst
- Study coordinator: Carrasco, Ruben D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.